Indications

Afun VT rectal preparation is indicated in vaginal itching, burning and discharge associated with recurrent vaginal yeast infections (Vaginal candidiasis) and also in viginitis due to Candida species as well as Mycotic infections complicated by other microorganisms sensitive to the drug.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Pharmacology

Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds and bacteroids. Clotrimazole is also active against certain gram-positive bacteria especially Staphylococci and Tricomonas. Like other imidazoles, Clotrimazole alters the permeability of fungal cell walls by interfering with cell wall lipids. At fungi static levels the main effect is inhibition of ergosterol synthesis but at higher concentrations there is an additional mechanism of membrane damage unrelated to sterol synthesis.

Dosage

Clotrimazole 100 mg & 200 mg vaginal preparation-

• First infections: In general, a 3-day treatment is sufficient for Candida vaginitis. On 3 consecutive nights, Clotrimazole 200 mg vaginal preparation is inserted as deeply as possible into the vagina. This is best achieved when lying on one's back with the knees slightly bent.
• Re-infections: In general, a 6-day treatment is sufficient. This applies also to mixed infections with the above-mentioned causative organisms. On six consecutive nights, 1 Clotrimazole 100 mg vaginal preparation is inserted as deeply as possible into the vagina. If necessary, 2 Clotrimazole 100 mg (1 in the morning and 1 in the evening) or 1 Clotrimazole 200 mg daily can be used for 6-12 days. Treatment should be timed so as to avoid the menstrual period and be finished before the onset of menstruation. To avoid re-infection, the partner should undergo local treatment with Clotrimazole cream at the same time.

Clotrimazole 500 mg vaginal preparation: Single dose, complete treatment with one vaginal tablet. The tablet should be inserted as deeply as possible into the vagina. This is best achieved when lying on one's back with the knees slightly bent. It is recommended that the treatment should be timed so as to avoid the menstrual period. For prevention of re-infection the partner should be treated locally with Clotrimazole cream at the same time.

Clotrimazole vaginal preparation are colorless and do not stain the underwear.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Administration

• Pull out plunger until it stops. Place a vaginal tablet into the applicator
• Insert applicator containing the tablet carefully as deeply as possible into the vagina (best lying on your back)
• Push plunger until it stops, there by depositing the tablet into the vagina. Remove the applicator
• After use, remove plunger completely by pulling it out of the applicator
• Then wash it in warm (not boiling) soapy water, rinse and dry carefully

Note: Pregnant women must follow physician's instructions

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Interaction

No information is available.

Contraindications

It is contraindicated in patients with known hypersensitivity to any of the components of this product.

Side Effects

Since there is practically no Afun VT absorption through the vaginal skin, no systemic effect is expected. The local tolerance of Afun VT vaginal tablet is generally good. Local irritation or burning sensation may occur in a very few cases but these symptoms are not considered harmful.

Pregnancy & Lactation

It is recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician. Clotrimazole is very poorly absorbed into the blood and the body after application to the skin or the vagina. Studies in women in their second or third trimesters have demonstrated no ill effects. It is not known if Clotrimazole is secreted in breast milk. Clotrimazole suppository can be used during pregnancy, but only under the supervision of Physician.

Therapeutic Class

Drugs used in Vaginal and Vulval condition, Topical Antifungal preparations

Storage Conditions

Keep below 25°C temperature, away from light & moisture. Keep out of the reach of children.